Jul 19, 2017 · In a multicenter, double-blind trial, patients aged 18 to 80 years of both genders undergoing cytotoxic chemotherapy for leukemia or autologous bone marrow transplant received daily oral treatment of 400 mg fluconazole until neutropenia was resolved for 2 days, parenteral amphotericin B therapy was initiated, or a maximum duration of 60 days ...
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In patients with pulmonary mucormycosis, surgical treatment plus antifungal therapy also greatly improves outcome compared to the use of antifungal therapy alone (10, 79, 116, 127, 150). In one series, the mortality of patients treated with antifungal agents alone was 68%, versus 11% in patients treated with antifungal agents plus surgery ( 150 ).
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The duration of treatment for acute pulmonary histoplasmosis is 6–12 weeks, while that for PDH and chronic pulmonary histoplasmosis is ≥1 year. Antigen levels in urine and serum should be monitored during and for at least 1 year after therapy for PDH. Stable or rising antigen levels suggest treatment failure or relapse.
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vedolizumab as first-line treatment. The median duration of treatment with vedolizumab was 1.97 years (IQR=0.83). 33.3% of the patients required dose intensification. Effectiveness: 20.8% of patients achieved CR in the IP and 50% achieved CR in the MP (47.4% in patients with dose intensification and 51.7% with no intensification).
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Amphotericin is the best studied of the above anti-fungals, and remains the preferred initial therapy for mucormycosis, with treatment usually lasting for at least six weeks (although tailoring of therapy to individual circumstance and response is common) . Posaconazole may be used as salvage or suppressive therapy against mucormycosis .
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Total treatment duration is 3 months. After treatment, the chest CT in the follow-up showed that the size of the nodules was reduced ( Figure 4 ). After the end of the treatment for 3 months, chest radiography revealed no definitive relapse of mucormycosis ( Figure 5 ).
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The study prespecified a category for mucormycosis primary treatment, defined as 4 days or less of previous systemic antifungals. Patients were also eligible if they were intolerant or refractory to other antifungals.
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The FDA evaluated the benefit of CRESEMBA for the treatment of invasive mucormycosis based on one trial involving 37 patients. The study was conducted in 34 centers in North America, South America ...
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Mar 20, 2019 · Invasive mucormycosis and aspergillosis are difficult infections to treat and the cost of therapy adds additional burden to the United States healthcare system. In 2009, it was estimated that each case of mucormycosis results in an average cost of $97,743, totaling over $50 million per year . Monitoring of therapeutic drug levels for certain ...
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Antachopoulos C, Gea-Banacloche JC, Walsh TJ. Zygomycosis (mucormycosis). In: Hospenthal DR, Rinaldi MG, eds. Diagnosis and treatment of human mycoses. New York, NY: Springer; 2008:227-243. Belongs to the polyene class of antifungals and is the most effective therapy against agents of mucormycosis.
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The diagnosis of pulmonary mucormycosis can be difﬁcult because it can mimic more common bacterial infections. In addition, many patients have a secondary bacterial infection, as seen in this case, leading to delay in diagnosis of the underlying pathogen as treatment with standard antibacterials is used.5,6 Sputum samples are
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Standard Approval Duration: 3 months Renewals will be considered on a case-by-case basis. Reimbursement Criteria: For the treatment of mucormycosis** in patients who have failed, have a contraindication to, or experienced intolerance to amphotericin B; OR For the step-down treatment of mucormycosis** in patients who have been initially